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Centre for Policy on Ageing | |
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Overdiagnosis in publicly organised mammography screening programmes
— systematic review of incidence trends | | Author(s) | Karsten Juhl Jorgensen, Peter C Gotzsche |
| Journal title | British Medical Journal, vol 339, no 7714, 25 July 2009 |
| Pages | pp 206-209 |
| Source | www.bmj.com |
| Keywords | Older women ; Cancer ; Screening ; Diagnosis ; Literature reviews. |
| Annotation | A systematic review of published trends in incidence of breast cancer before and after the introduction of mammography screening was conducted using PubMed (April 2007). One author extracted data on incidence of breast cancer (including carcinoma in situ), population size, screening uptake, time periods and age groups, which were checked independently by the other author. Linear regression was used to estimate trends of incidence both before and after the introduction of screening and in older, previously screened women. Meta-analysis was used to estimate the extent of overdiagnosis. Incidence data covering at least 7 years before screening and 7 years after screening had been fully implemented, and including both screened and non-screened age groups, were available from: the UK; Manitoba, Canada; New South Wales (NSW), Australia); Sweden; and parts of Norway. The implementation phase with its prevalence peak was excluded and adjustment made for changing background incidence and compensatory drops in incidence in older, previously screened women. Overdiagnosis was estimated at 52% (95% confidence interval 46% to 58%). Data from three countries showed a drop in incidence as the women exceeded the age limit for screening, but the reduction was small and the estimates of overdiagnosis was compensated for in this review. One in three breast cancers detected in a population offered organised screening is overdiagnosed. (RH). |
| Accession Number | CPA-090810211 A |
| Classmark | BD: CK: 3V: LK7: 64A * |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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