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Centre for Policy on Ageing | |
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Screening men for abdominal aortic aneurysm
— 10 year mortality and cost effectiveness results from the randomised Multicentre Aneurysm Screening Study | | Author(s) | S G Thompson, H A Ashton, L Gao |
| Corporate Author | Multicentre Aneurysm Screening Study Group |
| Journal title | British Medical Journal, vol 338, no 7710, 27 June 2009 |
| Pages | pp 1538-1541 |
| Source | www.bmj.com |
| Keywords | Older men ; Cardiovascular diseases ; Screening ; Cost effectiveness ; Death rate [statistics] ; Longitudinal surveys. |
| Annotation | In a sample of 67770 men aged 65-74 from four UK centres, participants were individually allocated to invitation to attend ultrasound screening or to a control group not offered screening. Patients with an abdominal aortic aneurysm detected at screening were offered surgery if they met predetermined criteria. Over 10 years, 135 deaths related to abdominal aortic aneurysm occurred in the invited group and 296 in the control group. The degree of benefit seen in earlier years of follow-up was maintained in later years. Based on the 10-year trial data, the incremental cost per man invited to screening was £100 (£82 to £118) leading to a cost-effectiveness ratio of £7600 (£5100 to £13000) per life year gained. However, the incidence of ruptured abdominal aortic aneurysms in those originally screened as normal increased noticeably after 8 years. The mortality benefit of screening men aged 65-74 for abdominal aortic aneurysm is maintained up to 10 years and cost-effectiveness becomes more favourable over time. To maximise the benefit from a screening programme, emphasis should be placed on achieving a high initial rate of attendance and good adherence to clinical follow-up, preventing delays to undertaking surgery and maintaining a low operative mortality after elective surgery. On the basis of current evidence, re-screening of those originally screened as normal is not justified. (RH). |
| Accession Number | CPA-090707501 A |
| Classmark | BC: CQ: 3V: WEC: S5: 3J * |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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