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Self administered cognitive screening test (TYM) for detection of Alzheimer's disease
 — cross sectional study
Author(s)Jeremy Brown, George Pengas, Kate Dawson
Journal titleBritish Medical Journal, vol 338, no 7708, 13 June 2009
Pagespp 1426-1428
Sourcewww.bmj.com
KeywordsDementia ; Assessment procedures for mental patients ; Cross sectional surveys.
AnnotationThe TYM ("test your memory"), a cognitive test designed to be suitable for non-specialist use, is evaluated for the detection of Alzheimer's disease (AD). This is a cross sectional study conducted in outpatient departments in three hospitals, including a memory clinic; 540 control participants aged 18-95 and 139 patients attending a memory clinic with dementia/amnestic mild cognitive impairment were involved. Results found that control participants completed the TYM with an average score of 47/50. Patients with Alzheimer's disease scored an average of 33/50. The TYM score shows excellent correlation with the two standard tests. A score of 42/50 had a sensitivity of 93% and specificity of 86% in the diagnosis of Alzheimer's disease. The TYM was more sensitive in detection of Alzheimer's disease than the Mini-Mental State Examination (MMSE), detecting 93% of patients compared with 52% for the MMSE. The negative and positive predictive values of the TYM with the cut off of 42 were 99% and 42% with a prevalence of Alzheimer's disease of 10%. Thirty one patients with non-Alzheimer dementias scored an average of 39/50. The TYM can be completed quickly and accurately by normal controls. It is a powerful and valid screening test for the detection of Alzheimer's disease. (KJ/RH).
Accession NumberCPA-090618202 A
ClassmarkEA: DA:4C: 3KB *

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