Centre for Policy on Ageing



A predictive depression pattern in mild cognitive impairment
Author(s)	Michèle Houde, Howard Bergman, Victor Whitehead
Journal title	International Journal of Geriatric Psychiatry, vol 23, no 10, October 2008
Pages	pp 1028-1033
Source	http://www.interscience.wiley.com
Keywords	Cognitive impairment ; Dementia ; Depression ; Diagnosis ; Correlation ; Longitudinal surveys ; Canada.
Annotation	The prognostic utility of the presence, persistence and patterns of depression in people with amnestic mild cognitive impairment (MCI) was evaluated. 60 amnestic MCI patients referred to a memory clinic in Quebec, Canada were assessed cognitively and for presence of depression using to 30-item Geriatric Depression Scale (GDS). They were followed annually for an average 4.3 years. Simple presence or absence of depression at referral did not predict progression of MCI to Alzheimer's disease (AD). Positive answers to specific GDS questions referring to "melancholic" affect as well as the persistence of depression over two or three years significantly predicted cognitive deterioration leading to AD. The affective characteristics of depression at referral and the presence of depression were better predictors of conversion to AD than the simple presence or absence of depression measured at referral time. (RH).
Accession Number	CPA-090605206 A
Classmark	E4: EA: ENR: LK7: 49: 3J: 7S
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...from the Ageinfo database published by Centre for Policy on Ageing.