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Centre for Policy on Ageing | |
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| Vascular factors and depression | | Author(s) | Emma Teper, John T O'Brien |
| Journal title | International Journal of Geriatric Psychiatry, vol 23, no 10, October 2008 |
| Pages | pp 993-1000 |
| Source | http://www.interscience.wiley.com |
| Keywords | Vascular diseases ; Depression ; Correlation ; Literature reviews. |
| Annotation | Possible mechanisms that may explain the bi-directional relationship between vascular disease and depression were examined in a literature review using Medline from 1996 to 2007 supplemented by key references to earlier work. Several mechanisms were considered, including autonomic dysfunction, platelet activation, hypothalamic pituitary axis activation, endothelial dysfunction, cytokines, omega 3 fatty acids, genetics, homocysteine and effects of treatment. The relationship between vascular disease and depression cannot solely be explained by current established risk factors of the effects of treatment for depression. Other mechanisms must apply, and there is some evidence for common genetic factors. Promising future lines of investigation include homocysteine, cytokines and endothelial dysfunction. More longitudinal studies combined with measurement of these biomarkers are needed. (RH). |
| Accession Number | CPA-090605203 A |
| Classmark | CQP: ENR: 49: 64A |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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