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Centre for Policy on Ageing | |
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Alzheimer's disease progression in the oldest old compared to younger elderly patient
— data from the REAL.FR study | | Author(s) | Fati Nourhashémi, Sophie Gillette-Guyonnet, Yves Rolland |
| Journal title | International Journal of Geriatric Psychiatry, vol 24, no 2, February 2009 |
| Pages | pp 149-155 |
| Source | http://www.interscience.wiley.com/journal/gps |
| Keywords | Dementia ; Cognitive processes ; Evaluation ; Octogenarians ; Young elderly ; Longitudinal surveys ; France. |
| Annotation | Although population-based studies have revealed marked increases in the prevalence and incidence of dementia, particularly in older age groups, longitudinal studies of cognitive change have been less frequently conducted. In this study of progression to Alzheimer's disease (AD) in the oldest-old, a cohort of 144 AD patients aged 85+ and 572 AD patients aged under 85 living in the community at inclusion were monitored over 2 years in 16 centres of the French AD network (REAL.FR study). Each subject underwent extensive medical examination including functional activities of daily living (ADLs) and neuropsychological evaluation, including Mini Mental State Examination (MMSE) every 6 months. The observed decrease in MMSE performance in patients aged 85+ was -4.18±0.63 points during the 2-year follow-up (vs -4.62±0.25 in the younger group) with no statistically significant difference between the two groups. After adjusting for confounding factors, ADL score declined faster in the oldest old than in those aged under 85 during the 2-year follow-up: -1.73±0.19 vs -1.27±0.08. While the progression of cognitive impairment was identical in both groups, after adjustment for variables relating both to age and dependency, the progression of dependency was more rapid in those aged 85+. (RH). |
| Accession Number | CPA-090421208 A |
| Classmark | EA: DA: 4C: BBM: BBA: 3J: 765 |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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