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Diagnostic accuracy of 123I-FP-CIT SPECT in possible dementia with Lewy bodies
Author(s)John T O'Brien, Ian G McKeith, Zuzana Walker
Journal titleBritish Journal of Psychiatry, vol 194, no 1, January 2009
Pagespp 34-39
Sourcehttp://bjp.rcpsych.org
KeywordsDementia ; Symptoms ; Screening ; Computers ; Diagnosis ; Longitudinal surveys.
Annotation123I-FP-CIT SPECT (single photon emission computed tomography) can help in the differential diagnosis of probable dementia with Lewy bodies (Lewy body dementia) and Alzheimer's disease (AD). The authors' aim was to determine the accuracy of 123I-FP-CIT SPECT in diagnosing people with possible dementia with Lewy bodies. They undertook a 12-month follow-up of 325 individuals with probable or possible Lewy body or non-Lewy body dementia which had previously undergone 123I-FP-CIT SPECT. A consensus panel, masked to SPECT findings, established diagnosis at 12 months in 254 people. Of 44 people with possible dementia with Lewy bodies at baseline, at follow-up the diagnosis for 19 was probable dementia with Lewy bodies (43%), in 7 people non-Lewy body dementia (16%) and for 18 individuals, it remained possible dementia with Lewy bodies (41%). Of the 19 who at follow-up were diagnosed with probable dementia with Lewy bodies, 12 had abnormal scans at baseline (sensitivity 63%); all 7 individuals with a possible diagnosis as having AD at follow-up had normal scans (specificity 100%). These findings confirm the diagnostic accuracy of 123I-FP-CIT SPECT in distinguishing Lewy body from non-Lewy body dementia, and also suggests a clinically useful role in diagnostically uncertain cases, as an abnormal scan in a person with possible dementia with Lewy bodies is strongly suggestive of dementia with Lewy bodies. (RH).
Accession NumberCPA-090305204 A
ClassmarkEA: CT: 3V: 3O: LK7: 3J

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