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Centre for Policy on Ageing | |
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| Vascular compliance is reduced in vascular dementia and not in Alzheimer's disease | | Author(s) | Sasha Dhoat, Khalid Ali, Christopher J Bulpitt |
| Journal title | Age and Ageing, vol 37, no 6, November 2008 |
| Pages | pp 653-658 |
| Source | http://www.ageing.oupjournals.org |
| Keywords | Blood pressure ; Dementia ; Clinical surveys. |
| Annotation | The authors determined vascular stiffness in patients with a clinical and radiological diagnosis of either Alzheimer's disease (AD) or vascular dementia (VaD), and compared them to normal age- and sex-matched controls. 16 patients with late onset AD, 13 with VaD and 16 age- and sex-matched controls were recruited to this study. Mean age was 77.7 ±8.3 years in the AD group, 789.7 ±8.9 years in the VaD group, and 76.4 ±6.9 years in the controls. Central arterial compliance (CAC) was significantly lower in subjects with VaD compared to the other two groups; augmentation index (AI) was significantly higher in the VaD group compared with the other two groups; and pulse wave velocity (PWV) in the muscular and elastic arteries were not statistically different between the three groups but tended to be highest in the VaD group for carotid-radial measurements. The reduced CAC and increased AI in VaD subjects indicate that the disease process is associated with less vascular compliance of the large elastic arteries in these patients, but not in patients with AD. (RH). |
| Accession Number | CPA-081217205 A |
| Classmark | BKL: EA: 3G |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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