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Centre for Policy on Ageing | |
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Severity of depression and risk for subsequent dementia
— cohort studies in China and the UK | | Author(s) | Ruoling Chen, Zhi Hu, Li Wei |
| Journal title | British Journal of Psychiatry, vol 193, November 2008 |
| Pages | pp 373-377 |
| Source | http://bjp.rcpsych.org |
| Keywords | Depression ; Dementia ; Correlation ; Comparison ; Longitudinal surveys ; China ; England. |
| Annotation | Depression and dementia often exist concurrently. The authors aimed to determine the effects of depressive syndromes and cases of depression on the risk of incident dementia. Participants in China and the UK aged 65+ without dementia were interviewed using the Geriatric Mental State (GMS). 1254 Chinese were interviewed and re-interviewed 1 year later; and 3341 and 2157 British participants (from the Ageing in Liverpool Project Health Aspects part of the Medical Research Council Cognitive Function and Ageing Study, MRC CFAS) were interviewed and re-interviewed 2 and 4 years later respectively. Incident dementia was associated with only the most severe depressive symptoms in both Chinese and British participants. The risk of dementia increased, not in the less severe cases of depression, but in the most severe cases. The multiple adjusted hazard ratio (HR)=5.44 in Chinese participants at 1-year follow-up, and HR=2.47 and 2.62 in British participants at 2- and 4-year follow-ups respectively. The effect was greater in younger participants. Only the most severe syndromes and cases of depression are a risk factor in dementia. (RH). |
| Accession Number | CPA-081121201 A |
| Classmark | ENR: EA: 49: 48: 3J: 7DC: 82 |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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