Centre for Policy on Ageing



Total serum cholesterol levels and Alzheimer's dementia in patients with Down syndrome
Author(s)	V P Prasher, E Airuehia, A Patel
Journal title	International Journal of Geriatric Psychiatry, vol 23, no 9, September 2008
Pages	pp 937-942
Source	http://www.interscience.wiley.com
Keywords	Dementia ; Cognitive impairment ; Endocrine systems ; Evaluation ; West Midlands.
Annotation	The risk for dementia in Alzheimer's disease (DAD) in adults with Down syndrome (DS) is higher than in the general adult population. Hypercholesterolaemia has been reported as a risk factor for DAD in the general population. This study investigated the role of serum cholesterol levels in the onset of DAD in the DS population. Subjects were 179 DS people (with and without DAD), part of the West Midlands Down Syndrome Research Group study. The possible association between Apolipoprotein E and amyloid beta 1-40 and beta 1-42 levels was also investigated. No statistically significant association was found between total serum cholesterol levels and dementia in AD or with amyloid beta levels. However, for DS adults with an apoE e4 allele, significantly higher serum cholesterol levels were found. Such individuals should be screened regularly. (RH).
Accession Number	CPA-081009204 A
Classmark	EA: E4: BKH: 4C: 87
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...from the Ageinfo database published by Centre for Policy on Ageing.