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Centre for Policy on Ageing | |
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Mild cognitive impairment in the older population
— who is missed and does it matter? | | Author(s) | Blossom C M Stephan, Carol Brayne, Ian G McKeith |
| Journal title | International Journal of Geriatric Psychiatry, vol 23, no 8, August 2008 |
| Pages | pp 863-871 |
| Source | http://www.interscience.wiley.com |
| Keywords | Cognitive impairment ; Dementia ; Screening ; Longitudinal surveys ; Cambridgeshire ; Newcastle upon Tyne ; Nottingham ; Oxford ; Gwynedd. |
| Annotation | The magnitude of missed "at risk" cases in the application of different mild cognitive impairment (MCI) criteria in the population is unknown. The authors used data from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS), a large population-based study of older aged individuals in Cambridgeshire, Newcastle, Nottingham, Oxford, Gwynedd and Liverpool. Prevalence and 2-year progression to dementia in individuals where impairment failed to fulfil published criteria for MCI was evaluated. Prevalence estimates of individuals not classified from current MCI definitions were extremely variable (range 2.5% to 41%). Rates of progression to dementia in these non-classified groups were also very variable (1.7% to 30%), reflecting heterogeneity in MCI classification requirements. Narrow definitions of MCI developed for clinical settings when applied in the population result in a large proportion of individuals who progress to dementia being included from MCI classifications. More broadly defined criteria would be better for selection of individuals at risk of dementia in population settings, but at the possibility of high false positive rates. While exclusion may be a good thing in the population since most people are presumably "normal", over-inclusion is more likely to be harmful. Further work needs to investigate the best classification system for application in the population. (RH). |
| Accession Number | CPA-080819220 A |
| Classmark | E4: EA: 3V: 3J: 8C: 86A: 8NTF: 8OC: 98 |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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