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Centre for Policy on Ageing | |
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Effects of different regimens to lower blood pressure on major cardiovascular events in older and younger people
— meta-analysis of randomised trials | | Corporate Author | Blood Pressure Lowering Treatment Trialists' Collaboration (BPLTTC), Institute of International Health, University of Sydney |
| Journal title | British Medical Journal, vol 336, no 7649, 17 May 2008 |
| Pages | pp 1121-1123 |
| Source | http://www.bmj.com |
| Keywords | Blood pressure ; Drugs ; Cardiovascular diseases ; Cross sectional surveys ; Clinical surveys ; Literature reviews. |
| Annotation | Meta-analyses and meta-regression analyses were used to compare the effects on the primary outcome between two age groups (under 65 and age 65+) for major cardiovascular events. Evidence for an interaction between age and the effects of treatment sought by fitting age as a continuous variable and estimating overall effects across trial. 31 trials, with 190609 participants, were included. The meta-analyses showed no clear differences between age groups in the effects of lowering blood pressure or any differences between the effects of the drug classes on major cardiovascular events. Neither was there any significant interaction between age and treatment when age was fitted as a continuous variable. The meta-regressions showed no difference in effects between the two age groups for the outcome of major cardiovascular events. Reduction of blood pressure produces benefits for younger and older adults, with no strong evidence that protection against major cardiovascular events afforded by different drug classes varies substantially with age. (RH). |
| Accession Number | CPA-080521203 A |
| Classmark | BKL: LLD: CQ: 3KB: 3G: 64A * |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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