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Centre for Policy on Ageing | |
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| Differentiation of semantic dementia and Alzheimer's disease using the Addenbrooke's Cognitive Examination (ACE) | | Author(s) | R Rhys Davies, Kate Dawson, Emelda Mioshi |
| Journal title | International Journal of Geriatric Psychiatry, vol 23, no 4, April 2008 |
| Pages | pp 370-375 |
| Source | http://www.interscience.wiley.com |
| Keywords | Dementia ; Diagnosis ; Assessment procedures for mental patients. |
| Annotation | The Addenbrooke's Cognitive Examination (ACE) is a simple diagnostic tool bridging the gap between the very brief Mini Mental State Examination (MMSE) and much longer test batteries used by neuropsychologists which has proven extremely population internationally. The ability of the ACE to differentiate semantic dementia (SD) from Alzheimer's disease (AD) was assessed with three groups: 40 SD patients, and two separate groups of AD patients (40 in each), matched to overall ACE or MMSE score. Significant differences were found between SD and both AD groups for the ACE sub-scores of naming, reading and orientation in time. Discriminant analysis (SD vs AD) led to formulation of a 'semantic index' (naming plus reading minus scores for serial-7s, orientation in time and drawing). Application of the semantic index to the patient data found values of less than zero to be predictive of SD rather than AD with 88% sensitivity and 90% specificity. Validation analysis in an independent sample of 24 SD and AD patients proved even more favourable. The overall ACE score is known to be a sensitive, and specific, indicator of early neurodegenerative dementia. This study shows that the ACE can be used to detect SD through application of the semantic index. (RH). |
| Accession Number | CPA-080430208 A |
| Classmark | EA: LK7: DA:4C |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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