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Centre for Policy on Ageing | |
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Factors associated with antidepressant use in depressed and non-depressed community-dwelling elderly
— the three-city study | | Author(s) | Agnès Soudry, Carole Dufouil, Karen Ritchie |
| Journal title | International Journal of Geriatric Psychiatry, vol 23, no 3, March 2008 |
| Pages | pp 324-330 |
| Source | http://www.interscience.wiley.com |
| Keywords | Depression ; Drugs ; Usage [services] ; Correlation ; France. |
| Annotation | The Three City Study (3C) is a community-based study of people aged 65+ in Bordeaux, Dijon and Montpellier. The present study of 7868 French people aged 65+ used the Center for Epidemiological Studies-Depression scale (CES-D) and the Mini International Neuropsychiatric Interview to define three groups: non-depressed, high depressive symptoms (HDS), and current major depressive disorders (MDD). Separate analyses were performed to identify the factors which were associated with antidepressant use in each group. Antidepressant use (55% selective serotonin re-uptake inhibitors - SSRIs, 25% tricyclic antidepressants, 20% other types) increased from 4.9% in non-depressed subjects to 17.3% in HDS, and 33.6% in those with current MDD. The factors associated with antidepressant use varied according to depression status. In particular, men with current MDD were more often treated with antidepressants than women, whereas in both the HDS and non-depressed groups, antidepressant use was, as has been observed elsewhere, more frequent in women. Gender also had a strong modifying effect on the relationship between antidepressant use and history of major depression. Finally, the direction of the association between antidepressant use and cognitive performance varied according to depression status. This study showed that the direction and strength of the association between antidepressant use and demographic and health-related factors varied according to the severity of depression symptoms. Further studies are needed to clarify the relationship between gender, cognition and antidepressant use. (RH). |
| Accession Number | CPA-080430206 A |
| Classmark | ENR: LLD: QLD: 49: 765 |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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