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Centre for Policy on Ageing | |
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Late-life depression and mortality
— influence of gender and antidepressant use | | Author(s) | Joanne Ryan, Isabelle Carriere, Karen Ritchie |
| Journal title | British Journal of Psychiatry, vol 192, January 2008 |
| Pages | pp 12-18 |
| Source | http://bjp.rcpsych.org |
| Keywords | Depression ; Drugs ; At risk ; Death ; Older men ; Older women ; Correlation ; France. |
| Annotation | Depression may increase the risk of mortality among certain subgroups of older people, but the part played by antidepressants in the association has not been thoroughly explored. The aim of this study was to identify the characteristics of older populations who are most at risk of dying, as a function of depressive symptoms, gender and antidepressant use. The methods used were adjusted Cox proportional hazards models to determine the association between depression and/or antidepressant use and 4 year survival of 7363 community-dwelling older people from the Three City Study (3C) in Bordeaux, Dijon and Montpellier. Major depressive disorder was evaluated using a standardised psychiatric examination based on DSM-IV criteria, and depressive symptoms were assessed using the Center for Epidemiological Studies Depression scale (CES-D). Depressed men using antidepressants had the greatest risk of dying, with increasing depression severity corresponding to a higher hazard risk. Among women, only severe depression in the absence of treatment was significantly associated with mortality. It is concluded that the association between depression and mortality is gender dependent and varies according to symptom load and antidepressant use. (KJ/RH). |
| Accession Number | CPA-080124203 A |
| Classmark | ENR: LLD: CA3: CW: BC: BD: 49: 765 |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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