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Centre for Policy on Ageing | |
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Advice to use topical or oral ibuprofen for chronic knee pain in older people
— randomised controlled trial and patient preference study | | Author(s) | Martin Underwood, Deborah Ashby, Pamela Cross |
| Journal title | British Medical Journal, vol 336 no 7636, 19 January 2008 |
| Pages | pp 138-142 |
| Source | http://www.bmj.com |
| Keywords | Pain ; Musculoskeletal diseases ; Drugs ; Clinical surveys. |
| Annotation | Participants were people aged 50+ with knee pain: 282 in randomised trial and 303 in preference study, who wre advised to use either topical or oral ibuprofen for chronic knee pain. Changes in WOMAC (Western Ontario McMaster Universities) osteoarthritis index scores at 12 months were equivalent; and there were no differences in major adverse effects in the trial or study. The only significant differences in secondary outcomes were in the randomised trial: the oral group had more respiratory adverse effects (17% vs 7%), and more participants changed treatments because of adverse effects. In the topical group, more participants had chronic pain grade III or IV at 3 months, and more participants changed treatment because of ineffectiveness. Advice to use oral or topical preparations had an equivalent effect on knee pain over one year, and there are more minor side effects with oral non-steroidal anti-inflammatory drugs (NSAIDs). Topical NSAIDs may be a useful alternative to oral NSAIDs. (RH). |
| Accession Number | CPA-080122206 A |
| Classmark | CT7: CL: LLD: 3G * |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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