Centre for Policy on Ageing



Genetic variation and human aging — progress and prospects
Author(s)	David Melzer, Alison J Hurst, Tim Frayling
Journal title	Journals of Gerontology: Series A, Biological Sciences and Medical Sciences, vol 62A, no 3, March 2007
Pages	pp 301-307
Source	http://www.geron.org
Keywords	Biological ageing ; Longevity ; Literature reviews.
Annotation	The genetics of ageing has seen extraordinary progress over the last few decades, with animal models suggesting key roles for a number of metabolic pathways. However, humans outlive laboratory animals many times over, and only evidence from humans can ultimately identify the drivers of human ageing. The authors thematically review progress in identifying human genetic variants associated with longevity. They also look at the bigger picture in identifying genetic associates of disease and functioning and healthy ageing in older people. Although much of the existing evidence is fragmentary, recent exciting findings and robust methods are rapidly taking this field forward. (RH).
Accession Number	CPA-070926222 A
Classmark	BH: BGA: 64A
Data © Centre for Policy on Ageing

...from the Ageinfo database published by Centre for Policy on Ageing.