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Centre for Policy on Ageing | |
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Main morbidities recorded in the women's international study of long duration oestrogen after menopause (WISDOM)
— a randomised controlled trial of hormone replacement therapy in postmenopausal women | | Author(s) | Madge R Vickers, Alastair H MacLennan, Beverley Lawton |
| Journal title | British Medical Journal, vol 335 no 7613, 4 August 2007 |
| Pages | pp 239-244 |
| Source | http://www.bmj.com |
| Keywords | Health [elderly] ; Ill health ; Menopause ; Drugs ; Clinical surveys ; United Kingdom ; Australia ; New Zealand. |
| Annotation | Participants were postmenopausal women aged 50-69, patients at 384 general practices in the UK, 91 in Australia and 24 in New Zealand. At early closure of the trial, 56583 had been screened, 8980 entered run-in and 5692 (26% of target of 22300) had started treatment. This trial was prematurely closed during recruitment after a median follow-up of 11.9 months (total of 6498 women years) in those enrolled, after publication of early results from the women's health initiative study. The mean age of randomised women was 62.8 years. When combined hormone therapy (n=2196) was compared with placebo (n=2189) there was a significant increase in the number of major cardiovascular events and venous thromboembolisms. There were no statistically significant differences in numbers of breast or other cancers, cerebrovascular events, fractures and overall deaths. Comparison of combined hormone therapy versus oestrogen therapy (n=815) outcomes revealed no significant differences. Hormone replacement therapy (HRT) increases cardiovascular and thromboembolic risk when started many years after the menopause. The results are consistent with findings of the women's health initiative study and secondary prevention studies. Research is needed to assess the long term risks and benefits of starting HRT near the menopause, when the effect may be different. (RH). |
| Accession Number | CPA-070809202 A |
| Classmark | CC: CH: CC:BD: LLD: 3G: 8: 7YA: 7YN * |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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