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Centre for Policy on Ageing | |
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| Siblings of Okinawan centenarians share lifelong mortality advantages | | Author(s) | Bradley J Willcox, D Craig Willcox, Qimei He |
| Journal title | Journals of Gerontology: Series A, Biological Sciences and Medical Sciences, vol 61A, no 4, April 2006 |
| Pages | pp 345-354 |
| Source | http://www.geron.org |
| Keywords | Siblings ; Centenarians ; Longevity ; Japan. |
| Annotation | Okinawa, an isolated island prefecture of Japan, has among the highest prevalence of exceptionally long-lived individuals in the world. The authors therefore hypothesised that, within this population, genes that confer a familial survival advantage might have clustered. They analysed pedigrees of 348 centenarians with 1142 siblings, and compared sibling survival with that of the 1890 general population cohort. Both male and female centenarian siblings experienced approximately half the mortality of their birth cohort-matched counterparts. This mortality advantage was sustained and did not diminish with age in contrast to many environmentally based mortality gradients, such as education and income. Cumulative survival advantages for this centenarian sibling cohort increased over the life span, such that female centenarian siblings and a 2.58-fold likelihood, and male siblings and 5.43-fold likelihood, versus their birth cohorts, of reaching the age of 90. These data support a significant familial component to exceptional human longevity. (RH). |
| Accession Number | CPA-070504233 A |
| Classmark | SV: BBT: BGA: 7DT |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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