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Centre for Policy on Ageing | |
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Do symptoms of memory impairment correspond to cognitive impairment
— a cross sectional study of a clinical cohort | | Author(s) | H A Archer, F MacFarlane, S Price |
| Journal title | International Journal of Geriatric Psychiatry, vol 21, no 12, December 2006 |
| Pages | pp 1206-1212 |
| Source | http://www.interscience.wiley.com |
| Keywords | Dementia ; Memory disorders ; Cognitive impairment ; Symptoms ; Cross sectional surveys ; Clinical surveys. |
| Annotation | Symptoms of memory loss are a common complaint within the general population and a frequent reason for seeking medical advice. This study aims to characterise a cohort of individuals with symptoms of memory loss and varying memory impairment, who will be followed longitudinally with serial neuropsychology and neuroimaging to evaluate the clinical relevance of symptoms of memory loss. 58 subjects with symptoms of memory loss were recruited from the National Hospital for Neurology and Neurosurgery. Those with mild cognitive impairment (MCI) had an increased prevalence of APOE e4 allele, impaired performance on tests of memory, measures of IQ and naming compared to controls. Baseline brain volumes were decreased and ventricular size increased. Those with symptoms of memory loss but no cognitive impairment (SNCI) performed significantly worse on tests of memory than the control group. The MCI represents a group with multiple risk factors to progression to Alzheimer's disease (AD). The SNCI group may represent a heterogeneous group with some individuals in the early states of AD, while others' memory complaints are more likely linked to anxiety or personality traits. (RH). |
| Accession Number | CPA-070131213 A |
| Classmark | EA: EH: E4: CT: 3KB: 3G |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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