Centre for Policy on Ageing



Personality and behaviour changes mark the early stages of Alzheimer's disease in adults with Down's syndrome — findings from a prospective population-based study
Author(s)	Sarah L Ball, Anthony J Holland, Johnny Hon
Journal title	International Journal of Geriatric Psychiatry, vol 21, no 7, July 2006
Pages	pp 661-673
Source	http://www.interscience.wiley.com
Keywords	Dementia ; Early ; Cognitive impairment ; Personality ; Behaviour ; Longitudinal surveys.
Annotation	The early presentation of Alzheimer's disease (AD) in Down's syndrome (DS) is characterised by prominent personality and behaviour changes, associated with excessive dysfunction, providing support for the notion that the functions of the frontal lobes may be compromised early in the course of the disease in this population. This is the main finding from a follow-up with a population sample with DS first assessed in 1994, followed up 18 months later, and reassessed after a further 5 years. The present study focuses on the 55 individuals who took part in the second follow-up. Dementia diagnosis was made using the modified CAMDEX (Cambridge Examination for Mental Disorders of the Elderly) informant interview and neuropsychological assessment was undertaken using the CAMCOG (Cambridge Cognitive Examination). (RH).
Accession Number	CPA-060809210 A
Classmark	EA: 4J: E4: DK: DM: 3J
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...from the Ageinfo database published by Centre for Policy on Ageing.