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Centre for Policy on Ageing | |
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Risk factors for incident dementia in England and Wales: the Medical Research Council Cognitive Function and Ageing Study
— a population-based nested case-control study | | Author(s) | Agustin G Yip, Carol Brayne, Fiona E Matthews |
| Corporate Author | MRC Cognitive Function and Ageing Study (MRC CFAS) |
| Journal title | Age and Ageing, vol 35, no 2, March 2006 |
| Pages | pp 154-159 |
| Source | http://www.ageing.oxfordjournals.org |
| Keywords | Dementia ; At risk ; Longitudinal surveys ; Cambridgeshire ; Gwynedd ; Newcastle upon Tyne ; Nottingham ; Oxford. |
| Annotation | This large UK-based multicentre study examined longitudinal risk of dementia in representative populations. Subjects were 6,075 individuals aged 65+ from two rural areas (Cambridgeshire and Gwynedd) and three urban (Nottingham, Newcastle and Oxford), from a detailed assessment group with risk measured at baseline. Incident dementia was measured at 2 and 6 years. Logistic regression analyses indicated a strong increased risk with age, moderate risk with stroke and Parkinson's disease (PD), and minimal risk for female sex and higher levels of education. Good / excellent self-reported health is associated with long-term protective effect, but smoking and alcohol are not. A history of exposure to general anaesthesia (GA) was associated with reduced risk. Thus, some well-known risk factors for dementia, of vascular and Alzheimer's type, are confirmed but not others. The association between perceived health - a robust predictor of user health outcomes - and incident dementia, independently of other potential risks, warrants further study. (RH). |
| Accession Number | CPA-060517210 A |
| Classmark | EA: CA3: 3J: 8C: 98: 86A: 8NTF: 8OC |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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