Centre for Policy on Ageing
 

 
Unravelling the disease process
Author(s)Peter St George-Hyslop, Martin Rossor
Journal titleThe Lancet, vol 358, Supplement, December 2001
Pagesp s1 [Review 2001]
AnnotationThis brief article outlines the progress made in 2001 in treating Alzheimer's Disease. The first advance has been in understanding some of the genetic causes of the disease. The second area that has advanced is that of the molecular and cellular biology of this disease. Finally advances have taken place in the generation of partial models of Alzheimer's disease in transgenic mice that express mutant APP, PS1, or tau transgenes. Although these models do not produce an exact replica of human Alzheimer's Disease, they do closely resemble those seen in people. As for the future, the authors forecast that one area of importance will be the ability to detect individuals with early, subclinical Alzheimer's disease to prevent a widespread public health concern. (KJ).
Accession NumberCPA-060317206 A

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