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Centre for Policy on Ageing | |
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Prognosis of late life depression
— a three-year cohort study of outcome and potential predictors | | Author(s) | Robert C Baldwin, Andrew Gallagley, Mhairi Gourlay |
| Journal title | International Journal of Geriatric Psychiatry, vol 21, no 1, January 2006 |
| Pages | pp 57-63 |
| Source | http://www.interscience.wiley.com |
| Keywords | Depression ; Cerebrovascular diseases ; Longitudinal surveys ; Greater Manchester. |
| Annotation | Late-onset depression (LOD) has a poor prognosis which may be worsened by the presence of cerebrovascular disease. This study in Greater Manchester originally involved 50 patients with LOD and 35 healthy age-matched controls, followed up at 3 years. Baseline measures included neuroradiological and neuropsychological variables. Outcomes were assessed by mortality, progression to dementia and clinical course of depressive disorder. 62 of the original cohort (73%) agreed to be re-interviewed. 7 participants had died (all from the depressed group) and 6 developed dementia, all but one from the depressed group. Vascular dementia predominated (although not significantly so) among those with dementia at follow-up. For 28 depressed patients with complete follow-up data (36% of the original sample), poor prognosis was linked to several baseline variables of relevance to vascular damage. Biochemical risk factors for vascular damage may be fruitful avenue for future research in vascular depression. (RH). |
| Accession Number | CPA-060313215 A |
| Classmark | ENR: CQ5: 3J: 83 |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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