Centre for Policy on Ageing



Late onset major depression — clinical and treatment-response variability
Author(s)	Henry C Driscoll, James Basinski, Benoit H Mulsant
Journal title	International Journal of Geriatric Psychiatry, vol 20, no 7, July 2005
Pages	pp 661-667
Source	http://www.interscience.wiley.com
Keywords	Depression ; Late ; Psychiatric treatment ; United States of America.
Annotation	Data from the second Pittsburgh study of maintenance therapies in late-life depression (MTLD-II, covering 1999-2003) were analysed. The 210 patients recruited to the present study were grouped according to illness-course characteristics: 59 early onset (age 59 or earlier), 27 late onset with recurrent depression, and 95 late onset with single episode depression. Rates of response, remission, relapse and termination were similar in all three groups. However, patients with late onset, recurrent major depression took longer to respond to treatment than those with late onset single episode depression (12 weeks vs 8 weeks) and had more cognitive and functional impairment. Additionally, patients with recurrent depression (whether early or late) were more likely to require pharmacotherapy augmentation to achieve response than patients with a single lifetime episode. (RH).
Accession Number	CPA-050906212 A
Classmark	ENR: 4L: LP: 7T
Data © Centre for Policy on Ageing

...from the Ageinfo database published by Centre for Policy on Ageing.