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Obesity in middle age and future risk of dementia
 — a 27 year longitudinal population based study
Author(s)Rachel A Whitmer, Erica P Gunderson, Elizabeth Barrett-Connor
Journal titleBritish Medical Journal, vol 330, no 7504, 11 June 2005
Pagespp 1360-1362
Sourcehttp://www.bmj.com
KeywordsObesity ; Weight ; Dementia ; Correlation ; Longitudinal surveys ; United States of America.
AnnotationA recent study found that high body mass index (BMI) in old age is associated with increased risk of dementia in women, though BMI is an insensitive measure of adiposity in older people and the subclinical phase of dementia causes weight loss.This Northern California study considered 10,276 men and women who underwent detailed health evaluations between 1964 and 1973 when they were aged 40-45 and were still members of the health plan (Kaiser Permanente) in 1994. Between 1994 and 2003, dementia was diagnosed in 713 participants (6.9%). Obese people (BMI of 30+) had a 74% increased rate of dementia, whilst overweight people (BMI 25-29.9) had a 35% greater risk of dementia compared with those of normal weight (BMI 18.6-24.9). Compared with those in the lowest fifth, those in the highest fifth of the distribution of subscapular or tricep skinfold thickness had a 72% and 59% greater risk of dementia. Obesity in middle age increases the risk of future dementia independently of comorbid conditions. (RH).
Accession NumberCPA-050624202 A
ClassmarkCSA: 4X6: EA: 49: 3J: 7T *

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