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Centre for Policy on Ageing | |
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| Lower all-cause, cardiovascular, and cancer mortality in centenarians' offspring | | Author(s) | Dellara F Terry, Marsha A Wilcox, Maegan A McCormick |
| Journal title | Journal of the American Geriatrics Society, vol 52, no 12, December 2004 |
| Pages | pp 2074-2076 |
| Source | http://www.americangeriatrics.org http://www.blackwellpublishing.com |
| Keywords | Children [offspring] ; Centenarians ; Death rate [statistics] ; Cancer ; Cardiovascular diseases ; Cross sectional surveys ; United States of America. |
| Annotation | Family pedigree information was collected on 295 offspring of centenarians (from 106 families with a parent already enrolled in the US-wide New England Centenarian Study) and on 276 controls (from 82 control families) from 1997 to 2000. Controls were individuals whose parents were born in the same year as the centenarians, but at least one of whom died at average life expectancy. Centenarians' offspring had a 62% lower risk of all-cause mortality, a 71% lower risk of cancer-specific mortality, and an 85% lower risk of coronary heart disease-specific mortality. Significant differences were not found for other causes of death. However, of those who had died, centenarian offspring died at a significantly younger age than controls. The results suggest that mechanisms for survival to exceptional old age may go beyond the avoidance or delay of cardiovascular disease or cancer. Moreover, survival advantage of centenarian offspring may not be due to factors related to childhood mortality. Ultimately, survival to exceptional old age may involve lower susceptibility to a broad range of age-related diseases, perhaps secondary to inhibition of basic mechanisms of ageing. (RH). |
| Accession Number | CPA-050215210 A |
| Classmark | SS: BBT: S5: CK: CQ: 3KB: 7T |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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