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Centre for Policy on Ageing | |
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| Comparison of fracture, cardiovascular event, and breast cancer rates at 3 years in postmenopausal women with osteoporosis | | Author(s) | Stuart L Silverman, Pierre D Delmas, Pandurang M Kulkarni |
| Journal title | Journal of the American Geriatrics Society, vol 52, no 9, September 2004 |
| Pages | pp 1543-1548 |
| Source | http://www.americangeriatrics.org http://www.blackwellpublishing.com |
| Keywords | Older women ; Osteoporosis ; Menopause ; Fractures ; Cardiovascular diseases ; Cancer ; Comparison ; Longitudinal surveys ; International. |
| Annotation | The double-blind, randomised placebo-controlled Multiple Outcomes of Raxolitene Evaluation trial (MORE) collected data on fracture, cardiovascular event and breast cancer from 2,565 postmenopausal women (mean age 67) with osteoporosis who were given calcium (500 mg/d) and vitamin D (400-600 IU/d) supplements. The occurrence of any fracture was the most common event in these women. In the 1,627 women without prevalent vertebral fractures,. the event rates per 1,000 patient years were 45.4 for any fracture, 15.2 for vertebral fracture, 4.7 for clinical vertebral fracture, 0.9 for hip fracture, 8.3 for any cardiovascular event, and 5.2 for all breast cancer. In 938 women with prevalent vertebral fractures, the event rates per 1,000 patient years were 117.4 for any new fracture, 77.1 for new vertebral fracture, 25.7 for clinical vertebral fracture, 5.8 for hip fracture, 15.1 for any cardiovascular event, and 2.8 for all breast cancer. The effect of prevalent fracture status on event rates was not dependent on whether women were older or younger than 65, but women aged 65+ had a 3.6 times greater occurrence of cardiovascular events than younger women, irrespective of prevalent fracture status. (RH) |
| Accession Number | CPA-041130238 A |
| Classmark | BD: CLO: CC:BD: CUF: CQ: CK: 48: 3J: 72 |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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