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Centre for Policy on Ageing | |
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Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age
— a prospective population based study | | Author(s) | Tiia Anttila, Eeva-Liisa Helkala, Matti Viitanen |
| Journal title | British Medical Journal, vol 329, no 7465, 4 September 2004 |
| Pages | pp 539-542 |
| Source | http://www.bmj.com |
| Keywords | Alcoholic beverages ; Middle aged ; Young elderly ; Cognitive impairment ; Dementia ; Early ; Finland. |
| Annotation | Alcohol consumption in middle age was evaluated for 1464 Finnish men and women aged 65-79 from population based samples studied in 1972 or 1977; 1018 (70%) were re-examined in 1998 (after an average follow-up of 23 years). Participants who drank no alcohol at midlife and those who drank alcohol frequently were both twice as likely to have mild cognitive impairment in old age as those participants who drank alcohol infrequently. The risk of dementia related to alcohol drinking was modified by the presence of the apolipoprotein e4 allele. The carriers of apolipoprotein e4 had an increased risk of dementia with increasing alcohol consumption compared with non-carriers who never drank. Alcohol drinking in middle age showed a U-shaped relation to risk of mild cognitive impairment in old age. Risk of dementia increased with increasing alcohol consumption only in those individuals carrying the apolipoprotein e4 allele. (RH). |
| Accession Number | CPA-041004204 A |
| Classmark | YPP: SE: BBA: E4: EA: 4J: 76L * |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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