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Centre for Policy on Ageing | |
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| The close relationship between biological aging and age-associated pathologies in humans | | Author(s) | Robin Holliday |
| Journal title | Journals of Gerontology: Series A, Biological Sciences and Medical Sciences, vol 59A, no 6, June 2004 |
| Pages | pp 543-546 |
| Source | http://www.geron.org |
| Keywords | Biological ageing ; Ill health. |
| Annotation | In the last 100 years, there has accumulated a vast amount of information about the changes that accompany ageing in a wide range of animal species. At the same time, there has been extensive documentation regarding the onset and characteristics of age-associated pathologies of humans and other mammals. It is argued that the totality of all this information is interrelated and provides a very extensive description of the deleterious changes in molecules, cells, tissues and organs, which accompany both ageing and many age-associated diseases. The accumulation of damage is in DNA, proteins, membranes, and organelles, as well as the formation of insoluble protein aggregates. The evolved design of many organ systems, such as the cardiovascular system, the brain and the eye, are incompatible with indefinite survival. The eventual failure to maintain the integrity of tissues and organs is the end result of the multiple causes of ageing. (RH). |
| Accession Number | CPA-040817208 A |
| Classmark | BH: CH |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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