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Drug treatment of REM sleep behavior disorders in dementia with Lewy bodies
Author(s)Gloria Massironi, Samantha Galluzzi, Giovanni B Frisoni
Journal titleInternational Psychogeriatrics, vol 15, no 4, December 2003
Pagespp 377-384
Sourcewww.springerpub.com
KeywordsDementia ; Sleep disorders ; Drugs ; Italy.
AnnotationDementia with Lewy bodies (DLB) is often associated with rapid eye movement (REM) sleep behaviour disorders (RBD). In contrast to the usual paralysis of REM sleep, this is characterised by violent motor and verbal activity. The pharmacological management of RBD was investigated in three DLB patients treated with clonazepam, a benzodiazepine used as an anti-epileptic, or donepezil, a cholinesterase inhibitor. All three patients had marked improvement. The pharmacodynamic mechanisms underlying the efficacy of the two drugs might be due to facilitator effect on the pedunculopontine nucleus, a key structure in the physiology of REM sleep. (RH).
Accession NumberCPA-040604202 A
ClassmarkEA: CTS: LLD: 76V

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