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Centre for Policy on Ageing | |
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| Is there an antiaging medicine? | | Author(s) | Robert N Butler, Michael Fossel, S Mitchell Harman |
| Journal title | Journals of Gerontology: Series A, Biological Sciences and Medical Sciences, vol 57A, no 9, September 2002 |
| Pages | pp B333-B338 |
| Keywords | Biological ageing ; Diseases ; Drugs ; Alternative medicine ; Preventative medicine ; Literature reviews. |
| Annotation | Despite much hype to the contrary, there is no convincing evidence that existing so-called "anti-ageing" remedies promoted by various companies can slow ageing or increase longevity. Nonetheless, a variety of experiments with laboratory animals indicate that ageing rates and life expectancy can be altered. Research going back to the 1930s has shown that caloric restriction (also called dietary restriction) extends life expectancy by 30%-40% in experimental animals, presumably at least partially by delaying the occurrence of age-dependent diseases. Mutations that decrease production of insulin growth factor 1 in laboratory mammals, and those that decrease insulin-like signalling in nematodes and fruit flies, have also increased life expectancy. Other strategies that appear promising include interventions that reduce oxidative stress and/or increase resistance to stress. Hormone and cell replacement therapies may also have value in dealing with specific age-related pathologies. This article reports the findings of a consensus workshop on what is known about existing and future interventions to slow, stop or reverse ageing in animals, and how these might be applied to humans through research. (RH). |
| Accession Number | CPA-021022211 A |
| Classmark | BH: CJ: LLD: LK3: LK2: 64A |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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