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Centre for Policy on Ageing | |
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Sleep/wake cycle disturbance in Alzheimer's disease
— how much is due to an inherent trait | | Author(s) | Jerome A Yesavage, Joy L Taylor, Helena Kraemer |
| Journal title | International Psychogeriatrics, vol 14, no 1, 2002 |
| Pages | pp 73-82 |
| Keywords | Sleep disorders ; Sleep behaviour ; Dementia ; Variance analysis ; Longitudinal surveys ; United States of America. |
| Annotation | Major advances in understanding the physiology and genetics of circadian rhythm in the past decade challenge the researcher of sleep/wake disorders in Alzheimer's disease (AD) to distinguish patient characteristics stable across the course of illness ("traits") from characteristics that vary with stage of illness ("states"). A components of variance approach with a repeated measures model was used to examine between-subjects variance over time ("trait") vs within-subjects ("state") variance in 42 patients with probable AD followed, on average, over 2 years, on actigraphic sleep/wake measures. Mental status scores indexed stage of illness. Actigraphic measures of sleep efficiency and circadian rhythmicity appeared predominantly "trait", with between-individual differences accounting for over 55% of variance, compared to the less than 5% of variance related to stage of cognitive impairment. The authors discuss how "state-trait" analyses can be helpful in identifying areas of assessment most likely to be fruitful objectives of physiological and genetic research on sleep/wake disturbance in AD. (RH). |
| Accession Number | CPA-020808204 A |
| Classmark | CTS: CG: EA: 3YA: 3J: 7T |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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