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Centre for Policy on Ageing | |
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| Sex hormones and cognitive function in older men | | Author(s) | Kristine Yaffe, Li-Yung Lui, Joeseph Zmuda |
| Journal title | Journal of the American Geriatrics Society, vol 50, no 4, April 2002 |
| Pages | pp 707-712 |
| Keywords | Older men ; Sexual activity ; Drugs ; Mental health [elderly] ; Correlation ; United States of America. |
| Annotation | While recent studies have suggested that oestrogen may improve cognitive function or prevent cognitive decline in older women, little research has been conducted regarding the hypothesis that testosterone - either directly or indirectly by conversion to oestrogens - may improve cognitive function in older men. The Mini-Mental State Examination (MMSE), Trails B, and Digit Symbol were used to measure the cognitive function of 310 American men (mean age 73, enrolled in the Study of Osteoporotic Risk in Men). Their sex hormone levels were determined by radiocommunoassay from serum. No consistent association between total testosterone level and cognitive test scores was observed. However, men with high bioavailable (loosely protein-bound) testosterone had better cognitive scores on all tests. Bioavailable measures of testosterone may better reflect hormone levels available to the brain, and thus be more closely associated with central nervous system outcomes such as cognition. (RH). |
| Accession Number | CPA-020701207 A |
| Classmark | BC: BIU: LLD: D: 49: 7T |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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