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Centre for Policy on Ageing | |
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| Negative symptoms, depression and Alzheimer's disease | | Author(s) | Martine Vercelletto, Florence Martinez, Sophie Lanier |
| Journal title | International Journal of Geriatric Psychiatry, vol 17, no 4, April 2002 |
| Pages | pp 383-392 |
| Keywords | Depression ; Dementia ; Symptoms ; Evaluation ; France. |
| Annotation | The present French study attempted to differentiate depressive symptoms from negative symptoms (NS) in mild-to-moderate Alzheimer's disease (AD) by applying behavioural scales used in psychiatry, and compared forms of AD with predominant NS with frontal lobe hyperfusion in functional imaging. An apolipoprotein E (APO E) genotype was performed systematically to determine whether NS forms corresponded to a particular APO E pattern. Patients with a mild-to-moderate form of AD did not manifest a true depressive syndrome, and had Montgomery and Asberg Depression Scale (MADRS) scores similar to those of control subjects. However, the NS observed in the absence of depression could not account for modifications in personality related to early apathy and lack of motivation in AD. This consideration is important in distinguishing between depression and dementia. (RH). |
| Accession Number | CPA-020520214 A |
| Classmark | ENR: EA: CT: 4C: 765 |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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