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Centre for Policy on Ageing | |
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| Physical disorders and causes of death in relatives of Alzheimer's disease patients | | Author(s) | M Kockler, A Nitardy, A Papassotiropoulos |
| Journal title | International Journal of Geriatric Psychiatry, vol 17, no 4, April 2002 |
| Pages | pp 335-342 |
| Keywords | Dementia ; Depression ; Cardiovascular diseases ; Diseases of the blood ; Parkinson's disease ; Death ; The Family ; Correlation ; Germany. |
| Annotation | Genetic risk factors are important in Alzheimer's disease (AD), and may also predispose for other disorders. The risk of physical disorders in relatives of AD patients, of depressed patients and of control subjects were compared in a study undertaken at the Universities of Mainz and Bonn. Family history, and if possible, interview information on physical disorders and causes of deaths in relatives of 146 patients with AD, 168 with major depression (MD), and 136 controls was collected. The results did not support a major overlap between the genetic risk of AD and the genetic risk of cerebrovascular disease, Down's syndrome, haematological malignancies or Parkinson's disease. The finding of an increased risk of congenital malformations in relatives of AD patients needs further replication before it can be stated. The increased risk of dementia or depression with cognitive impairment in older relatives of patients with AD or MD increases the risk of accidents such as falls. The genetic risk of depression in relatives of those with MD could have a negative influence on the prognosis of peptic ulcers. (RH). |
| Accession Number | CPA-020520211 A |
| Classmark | EA: ENR: CQ: CQT: CR6: CW: SJ: 49: 767 |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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