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Deficits in controlled processing may predict dementia
 — a twin study
Author(s)Ross Andel, Margaret Gatz, Nancy L Pedersen
Journal titleJournals of Gerontology: Series B, Psychological Sciences and Social Sciences, vol 56B, no 6, November 2001
Pagespp P347-P355
KeywordsCognitive processes ; Cognitive impairment ; Dementia ; Twins ; Sweden.
Annotation33 pairs of twins from the Swedish Twin Study were tested for differential patterns of cognitive decline. Compared with non-demented twin partners, those who later developed dementia already showed poorer performance on tests of memory and attention, visuo-spatial reasoning skills, and perceptual speed and the Mini-Mental State Examination (MMSE). It is suggested that this cluster of tests reflects deficits in controlled rather than automatic cognitive processes. Non-demented twin partners of the twins who became demented were also compared with 33 matched controls selected from pairs in which both members remained non-demented. Non-demented twin partners scored lower than matched controls on tests of verbal ability, memory and attention, and perceptual speed and the MMSE. This finding indicates that non-demented twin partners of demented twins are at elevated risk themselves of becoming demented, and further suggests that certain areas of cognition are compromised prior to diagnosis of dementia. (RH).
Accession NumberCPA-020107211 A
ClassmarkDA: E4: EA: SVR: 76P

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