Centre for Policy on Ageing



Factors associated with mortality in patients with early-onset Alzheimer's disease — a five-year longitudinal study
Author(s)	Akinoro Ueki, Hidetaka Shinjo, Hiroko Shimode
Journal title	International Journal of Geriatric Psychiatry, vol 16, no 8, August 2001
Pages	pp 810-815
Keywords	Dementia ; Early ; Life span ; Death rate [statistics] ; Longitudinal surveys ; Japan.
Annotation	A longitudinal study of 108 Japanese patients (35 male, 75 female) with early-onset Alzheimer's disease (AD) and aged 46 to 64 at onset and 50 to 69 when diagnosed at the authors' institute aimed to identify neuropsychiatric and somatic factors related to survival. After 5 years, 30 had died; pneumonia was the most common cause (73%), followed by malignancy (20%), and heart disease (7%). Kaplan-Meier survival curves showed a lower survival rate in those with early-onset AD than in age- and sex-matched life table data in Japan. In Cox proportional hazards analysis, male gender, early disease onset, concurrent physical illness at time of diagnosis, and a low Mini-Mental State Examination (MMSE) score increased the likelihood of death in patients with early onset AD. The study confirmed that these patients have considerably excess mortality and a different pattern of cause of death than in the general population. (RH).
Accession Number	CPA-010928210 A
Classmark	EA: 4J: BG6: S5: 3J: 7DT
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...from the Ageinfo database published by Centre for Policy on Ageing.