Centre for Policy on Ageing



Early-onset Alzheimer's disease in Scotland — environmental and familial factors
Author(s)	Lawrence J Whalley
Journal title	The British Journal of Psychiatry, vol 178, supplement 40, April 2001
Pages	pp S53-S59
Keywords	Dementia ; Early ; Biological sciences ; Physical environment ; Research Reviews ; Scotland.
Annotation	Disease models to explain gene-environment interaction in cardiovascular disease are related to observations on Alzheimer's disease (AD). This article uses recent studies on genetic and environmental factors for AD to suggest a multi-factorial disease model. Putative risk factors from Scottish studies include increased paternal age in AD men and coal mining as paternal occupation in both AD and vascular dementia. Migration effects suggest that environmental factors in high incidence AD areas are important during adult life. The studies summarised do not provide sufficient data to support a single comprehensive disease model of gene-environment interaction in AD. Future studies will require very large sample sizes (more than 600), molecular genetic analysis, and environmental data that span neurodevelopment and the period between disease onset and appearance of clinical symptoms. (RH).
Accession Number	CPA-010418202 A
Classmark	EA: 4J: Y7: R: 3A:6KC: 9A
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...from the Ageinfo database published by Centre for Policy on Ageing.