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Centre for Policy on Ageing | |
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Relation between age-related decline in intelligence and cerebral white-matter hyperintensities in healthy octogenarians
— a longitudinal study | | Author(s) | Ellen Garde, Erik Lykke Mortensen, Katja Krabbe |
| Journal title | The Lancet, vol 356, no 9230, 19 August 2000 |
| Pages | pp 628-634 |
| Keywords | Octogenarians ; Mental ageing ; Dementia ; Nervous systems ; Tissues ; Longitudinal surveys ; Denmark. |
| Annotation | White-matter hyperintensities are commonly found on magnetic resonance imaging (MRI) of older people with or without dementia. Studies of the relation between severity of white-matter hyperintensities and cognitive impairment have had conflicting results. The authors undertook a longitudinal study of age-related decline in intellectual function and MRI of 698 Danish people born in 1914, of whom 68 healthy non-demented individuals had been tested with the Wechsler adult intelligence scale (WAIS) at ages 50, 60, 70, and 80, and cerebral MRI at age 80-82. Scores for periventrical hyperintensities in this sample included all possible degrees of severity, but no participant scored more than 75% of maximum for deep white-matter hyperintensities. Neither type was related to the WAIS IQs of the 80-year assessment, but both were significantly associated with decline in performance of IQ from age 50 to 80. An analysis based on two WAIS sub-tests showed that the association between white-matter hyperintensities and cognitive impairment was significant only for cognitive decline in the decade 70-80 years. The authors suggest that the results need to be interpreted with some caution. (RH). |
| Accession Number | CPA-001009214 A |
| Classmark | BBM: D6: EA: BKN: BKT: 3J: 76K * |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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