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Distinction between preclinical Alzheimer's disease and depression
Author(s)Pieter Jelle Visser, Frans R J Verhey, Rudolf W H M Ponds
Journal titleJournal of the American Geriatrics Society, vol 48, no 5, May 2000
Pagespp 479-484
KeywordsDementia ; Depression ; Cognitive impairment ; Diagnosis ; Netherlands.
Annotation111 non-demented patients with cognitive impairment aged over 55 from the Maastricht Memory Clinic were assessed for personal characteristics, the severity of depression, and cognitive functioning at baseline, and on the course of cognitive impairment and presence of dementia after 2 and 5 years. 25 patients had preclinical dementia with Alzheimer's type dementia at follow-up, of whom 15 were depressed at baseline. Those with depression and preclinical AD had a poorer performance on cognitive tasks and were older than those with depression-related cognitive impairment. Depression is common in preclinical AD. Depressed subjects with preclinical AD can be accurately differentiated from those with depression-related cognitive impairment by age and the severity of the memory impairment. Research that aims to investigate preclinical AD should not exclude a priori subjects with depression, because preclinical AD is often accompanied by depression. (RH).
Accession NumberCPA-000824212 A
ClassmarkEA: ENR: E4: LK7: 76H

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