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Has familial aggregation in Alzheimer's disease been overestimated?
Author(s)Jeremy M Silverman, Christopher M Smith, Deborah B Marin
Journal titleInternational Journal of Geriatric Psychiatry, vol 15, no 7, July 2000
Pagespp 631-637
KeywordsDementia ; The Family ; Age group distribution statistics ; Life expectancy tables ; United States of America.
AnnotationSurvival analysis was used to investigate whether estimates of familial aggregation of Alzheimer's disease (AD) based on a clinic-based AD proband (C-AD) sample of 544 (with 4265 first degree relatives) differ from one ascertained at a nursing home (NH-AD) of 225 probands (with 1772 first degree relatives). Cumulative survival from AD was significantly worse in the C-AD relatives, and the overall relative risk (RR) of AD in this group was greater than twice that of the relatives of the NH-AD group. However, age at onset in C-AD probands was significantly earlier than in the NH-AD group, and in both groups this factor was significantly associated with familial aggregation. (RH).
Accession NumberCPA-000823233 A
ClassmarkEA: SJ: S6: S7: 7T

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