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Centre for Policy on Ageing | |
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| Oestrogens and Alzheimer's disease | | Author(s) | Martin H Birkhäuser, Jindrich Strnad, Christian Kämpf |
| Journal title | International Journal of Geriatric Psychiatry, vol 15, no 7, July 2000 |
| Pages | pp 600-609 |
| Keywords | Dementia ; Drugs ; Menopause ; Behaviour ; Literature reviews. |
| Annotation | In the last decade, several reports suggest that oestrogen (or hormone) replacement therapy (ORT or HRT) might prevent or delay Alzheimer's disease (AD). Oestrogens influence and modulate brain structure and brain function. There are substantial arguments that postmenopausal oestrogen loss might, together with other factors, accelerate the appearance of AD. The evidence is suggestive, but not compelling, that HRT can reduce the relative risk to suffer from AD. Furthermore, recent findings are consistent with the hypothesis that oestrogens might ameliorate the symptomatology in early stages of AD. However, it has to be remembered that in most clinical trials that the number of oestrogen users was quite small, and, usually, oestrogen use was not randomised. The aim of the present review is to discuss the data available with regard to clinical relevance. (RH). |
| Accession Number | CPA-000823229 A |
| Classmark | EA: LLD: CC:BD: DM: 64A |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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