| |
Centre for Policy on Ageing | |
 | |
|
| Course of objective memory impairment in non-demented subjects attending a memory clinic and predictors of outcome | | Author(s) | Pieter Jelle Visser, Frans R J Verhey, Rudolf W H M Ponds |
| Journal title | International Journal of Geriatric Psychiatry, vol l5, no 4, April 2000 |
| Pages | pp 363-372 |
| Keywords | Memory disorders ; Geriatric out-patients clinics ; Longitudinal surveys ; Netherlands. |
| Annotation | The aim of this Dutch longitudinal study was to investigate the course of memory outcome, and to identify predictors of outcome. 74 non-demented subjects were included when they were aged 40+ and had a baseline score on the delayed recall of a word learning test below the tenth percentile. Those with memory impairment due to known somatic or neurological causes were excluded. Subjects were reassessed after 2 and 5 years. At the 5-year follow-up, 42% had no memory impairment, 19% had memory impairment without dementia, and 39% had Alzheimer type dementia (AD). Predictors at baseline of reversible memory impairment in a multivariate analysis were age, scores on the MMSE and delayed recall, and the degree of functional impairment. Predictors at baseline of AD were age and score on the MMSE. The apolipoprotein E genotype and presence of depression at baseline were not predictors of outcome. Memory impairment is often reversible and so its presence alone is not sufficient to consider subjects as pre-clinically demented. Predictive accuracy can be increased by including simple measures such as age, the scores on the MMSE and delayed recall, and the degree of functional impairment. (RH). |
| Accession Number | CPA-000823208 A |
| Classmark | EH: L6G: 3J: 76H |
Data © Centre for Policy on Ageing |
|
| ...from the Ageinfo database published by Centre for Policy on Ageing. |
| |
|