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Centre for Policy on Ageing | |
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| Person-specific paths of cognitive decline in Alzheimer's disease and their relation to age | | Author(s) | Robert S Wilson, David W Gilley, David A Bennett |
| Journal title | Psychology and Aging, vol 15, no 1, March 2000 |
| Pages | pp 18-28 |
| Keywords | Dementia ; Mental ageing ; Cognitive impairment ; Age groups [elderly] ; United States of America. |
| Annotation | Change in global and specific measures of cognitive function was studied in a cohort of 410 people with Alzheimer's disease (AD), who completed up to five annual evaluations: follow-up participation among survivors exceeded 90%. Average annual decline was 0.57 standard units (95% confidence interval [CI] 0.51 to 0.62) on a composite measure based on 17 individual tests and 3.26 points (95% CI 3.06 to 3.46) on the Mini Mental State Examination (MMSE), but substantial heterogeneity was apparent. On both global and specific measures, rate of cognitive decline was reduced in older persons compared with younger persons. A similar effect was observed for estimated age of disease onset. The effect of age was approximately linear and was not attributable to education, sex, race, other conditions that impair cognition, or mortality. The results indicate that person-specific paths of cognitive decline in AD vary substantially and suggest that in clinical settings some of this variability is related to age. (RH). |
| Accession Number | CPA-000613403 A |
| Classmark | EA: D6: E4: BB: 7T |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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