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Centre for Policy on Ageing | |
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| Relationships between mood and estradiol (E2) levels in Alzheimer's disease (AD) patients | | Author(s) | Linda E Carlson, Barbara B Sherwin, Howard M Chertkow |
| Journal title | The Journals of Gerontology Series B: Psychological Sciences and Social Sciences, vol 55B, no 1, January 2000 |
| Pages | pp P47-P53 |
| Keywords | Dementia ; Depression ; Older men ; Older women ; United States of America. |
| Annotation | Mood has been infrequently studied in people with Alzheimer's disease (AD). This study investigated the relationship between mood and estradiol (E2) levels and assessed the prevalence of mood symptoms in AD patients compared to healthy older controls. Fifty-two AD patients (23 men, 23 oestrogen non-using women, and 3 oestrogen-using women) were assessed. No differences were found between the AD patients and the controls in overall E2 levels, but, as expected, the women oestrogen-users in both the AD and control groups had higher E2 levels. There was a significant negative correlation between E2 levels and Geriatric Depression Scale (GDS) scores in the full sample, which was particularly strong in the oestrogen-using women. Overall, mood scores in the AD patients were higher than in the healthy controls, indicating higher levels of depressive symptomatology; the highest depression scores occurred in the AD women who were oestrogen non-users. (AKM). |
| Accession Number | CPA-000420405 A |
| Classmark | EA: ENR: BC: BD: 7T |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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