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Centre for Policy on Ageing | |
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| Clinical Lewy body dementia and the impact of vascular components | | Author(s) | Elisabet Londos, Ulla Passant, Arne Brun |
| Journal title | International Journal of Geriatric Psychiatry, vol 15, no 1, January 2000 |
| Pages | pp 40-49 |
| Keywords | Dementia ; Symptoms ; Sweden. |
| Annotation | Clinical records of 200 deceased patients from the Lund Longitudinal Dementia Study in Sweden who had undergone pathological post-mortem examination were studied retrospectively. 48 patients (24%) fulfilled the clinical criteria for dementia with Lewy bodies (DLB), while 45 (22%) fulfilled the clinical criteria for Alzheimer's disease (AD). The clinical LBD group showed a tendency towards a "frontal profile" with disinhibition, confusion, personality change and vocally disruptive behaviour. More than 80% of the AD and LBD groups exhibited Alzheimer pathology. The LBD group had frontal white matter pathology and degeneration of the substantia nigra more often than the clinical AD group. Both LBD and AD groups showed a progressive and marked increase in severity of dementia and decrease in activities of daily living (ADL) capacity according to an evaluation based on the Berger scale and Katz index. The condition of the LBD group was significantly worse earlier in dementia. It is important to recognise LBD symptomatology because of the ameliorating effects of cholinesterase inhibitors, and for choice of appropriate care, since there is such a rapid deterioration. (RH). |
| Accession Number | CPA-000419006 A |
| Classmark | EA: CT: 76P |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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