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Centre for Policy on Ageing | |
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| Risk factors accelerating cerebral degenerative changes, cognitive decline and dementia | | Author(s) | John S Meyer, Gaiane M Rauch, Kate Crawford |
| Journal title | International Journal of Geriatric Psychiatry, vol 14, no 12, December 1999 |
| Pages | pp 1050-1061 |
| Keywords | Cognitive impairment ; Dementia ; At risk ; Screening ; Evaluation ; United States of America. |
| Annotation | Factors accelerating cerebral degenerative changes represent potentially modifiable risks for cognitive decline. Putative risk factors accelerating subtle cognitive decline and dementia were correlated with repeated measures of cerebral atrophy, CT densitometry, perfusions and cognitive testing among 224 neurologically and cognitively normative ageing American volunteers (mean age at entry 59.5; mean follow-up at 4.3 years) At follow-up, 22 developed subtle cognitive decline, 19 became demented, 8 with vascular type (VAD), and 11 with Alzheimer's type (DAT), and 183 remained cognitively unchanged. After age 60, cerebral atrophy, ventricular enlargement, polio- and leuko-araiosis, geometrically increased as perfusions declined. Risk factors accelerating perfusional decline, cerebral atrophy, polio-araiosis and leuko-araiosis (thinning of grey-white matter densities) were: transient ischaemic attacks (TIAs), hypertension, smoking, hyperlipidemia, and male gender. At age 71.5 ±11.9, subtle cognitive decline began, accelerated by TIAs, hypertension and heart disease. Excessive cortical perfusional decreases and cerebral atrophy correlated with cognitive decline. Family history of neurodegenerative disease correlated with DAT. (RH). |
| Accession Number | CPA-000203207 A |
| Classmark | E4: EA: CA3: 3V: 4C: 7T |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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